Neural Electrodes with a Mounted Compact Miniscope for Freely Moving Animal

초록

Various types of multimodal neural interfaces have been recently proposed to understand the functional connectivity of neural circuits. In this paper, we present the multifunctional neural interface integrated with an electrocorticography (ECoG) electrode array and commercial micro-endoscope for parallelly recording ECoG signals and fluorescent images. The ECoG electrode array has high flexibility and transparency for integrating complex micro-endoscope and the simultaneous recording of fluorescence images and electrophysiological signals. A headstage was designed to tightly combine between ECoG array and micro-endoscope and miniaturized to minimize the behavioral restrictions of animals. The recording capability of the developed multifunctional neural interface has been demonstrated to perform the parallel recording of ECoG signals and fluorescent images in freely moving mice.