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LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition
- Kim, Beomsue;
- Suh, Young Ho;
- Joe, Eunhye
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5초록
An active actin dynamic is a crucial feature of brain microglia. Here we report that LRRK2, a primary familial Parkinson's disease-associated gene, negatively regulates microglia's actin dynamics. LRRK2 depolymerized filamentous actin (F-actin) by directly binding to it or inhibiting microglia's Rac-PAK signaling. LRRK2 knockdown resulted in a reduced ruffle and enhanced lamellipodia formation of ADP-activated microglia, altering the microglia's physiological activity to vigorous migration toward damaged cells. These results suggest that LRRK2 is a negative regulator for the controlled actin dynamics in microglia.
키워드
Actin depolymerization; F-actin-binding proteins; Leucine-rich repeat serine-threonine protein kinase-2; Parkinson disease 8; microglia; PARKINSONS-DISEASE; EXTRACELLULAR ATP; MUTATION; KINASE; ACTIVATION; INJURY; CELLS; ASTROCYTES; PROMOTES; BINDING
- 제목
- LRRK2 decreases microglial actin dynamics by filamentous actin depolymerization and Rac1 inhibition
- 저자
- Kim, Beomsue; Suh, Young Ho; Joe, Eunhye
- 발행일
- 2022-12
- 권
- 26
- 호
- 6
- 페이지
- 380 ~ 387
- 출판사
- 한국통합생물학회
- 발행국가
- 대한민국
- 분량
- 8 페이지
- ISSN
- E 2151-2485
P 1976-8354